Betekenis van:
germ cell

Voorbeeldzinnen

1. Germ cell mutagenicity (section 3.5);
2. Germ cell mutagenicity, Hazard Category 2
3. Specific considerations for classification of substances as germ cell mutagens
4. In vivo heritable germ cell mutagenicity tests, such as:
5. Because of their mechanism of action, germ cell mutagens are likely to have carcinogenic effects.
6. germ cell mutagenicity, category 1A, 1B or 2 (Annex I, section 3.5);
7. the substance is known to be carcinogenic category 1A or 1B or germ cell mutagenic category 1A, 1B or 2.’;
8. the substance is known to be a germ cell mutagen and appropriate risk management measures are implemented, or
9. For the purpose of classification for germ cell mutagenicity, substances are allocated to one of two categories as shown in Table 3.5.1.
10. If there is a positive result from an in vivo somatic cell study available, the potential for germ cell mutagenicity should be considered on the basis of all available data, including toxicokinetic evidence.
11. Germ cell mutagens are substances that can cause a permanent change in the amount or structure of the genetic material of a cell resulting in a change in the phenotypic characteristics of that cell, which may be transferred to descendent daughter cells.
12. Note: Substances which are positive in in vitro mammalian mutagenicity assays, and which also show chemical structure activity relationship to known germ cell mutagens, shall be considered for classification as Category 2 mutagens.
13. the substance is classified as germ cell mutagen category 2 or there is evidence from the repeated dose study(ies) that the substance is able to induce hyperplasia and/or pre-neoplastic lesions.’
14. ‘However, for substances meeting the criteria for classification in the hazard classes carcinogenicity, germ cell mutagenicity or reproductive toxicity, category 1A or 1B, in accordance with Regulation (EC) No 1272/2008, the review shall be carried out by 1 June 2014.’;
15. the identity of all substances in the mixture that contribute to the classification of the mixture as regards acute toxicity, skin corrosion or serious eye damage, germ cell mutagenicity, carcinogenicity, reproductive toxicity, respiratory or skin sensitisation, specific target organ toxicity (STOT) or aspiration hazard.