- extreme distress of body or mind
- suffer great pains or distress
- He is in anguish over her child.
- He hid his anguish with a smile.
- She takes a new lover while he is in anguish.
- The newspaper told of the mother's anguish at the death of her son.
- Adele watched her friend with dismay. Large tears flooded her face, she could not suppress this scream of anguish and pity: "Oh! Mary! poor Mary!".